Pyxis Discovery has designed and synthesized a library of fragments, which are based on scaffolds that are found in existing drugs. These novel and unique fragments are ‘Rule of 3’ compliant, diverse, filtered for undesirable chemistry and have built-in possibilities for follow-up chemistry. The Smart fragment library provides excellent starting points for fragment evolution programs and is suitable for any fragment screening platform.

98% of the fragments are soluble in DMSO at a concentration of 50 mM. Water solubility information is also available.

The database with structures of the fragments can be downloaded here in SDF and Excel format.

Download SDF                     Download XLS

For more information regarding the Smart fragment library, contact us at fragment@pyxis-discovery.com.